The JRP SIB06 BioQuaRT was structured into 7 work packages.

Work package 1, Microdosimetry, developed micro-calorimeter prototypes for the direct measurement of lineal energy and characterised their response for different ion beams by means of experiment and modelling. The performance of the micro-calorimeter was compared with existing microdosimeters, such as monolithic silicon telescopes and tissue-equivalent proportional counters to assess potential corrections to lineal energy spectra obtained from measured ionisation by these devices.

Work package 2, Nanodosimetry, developed techniques for the measurement of particle track structure on different length scales in the nanometre range. A measurement device integrating the same type of silicon microdosimeter as in WP1 and a nanodosimeter was constructed for first multi-scale measurement of particle track structure characteristics. After comparison with two other types of nanodosimeter this device was used for a multi-scale characterisation of radiation qualities employed in WP4.

Work package 3, Indirect Effects, investigated the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS). Options for imaging 2D or 3D distributions of the formation of ROS were investigated and a prototype system was built to measure the spatial distribution of the ROS formation in ion beams and to extract their production yields in ion beams.

Work package 4, (Radio-)Biology, focused on the biological aspects of radiation damage and produced data on initial DNA damage and late effects for ion beams of different radiation qualities. The biological data collected in this WP was used to validate the multi-scale model developed in WP5.

Work package 5, Multi-Scale Model, provided evaluated data sets of DNA cross-sections and developed a multi-scale model to address microscopic and nanometric track structure properties. This involved the development of Monte Carlo simulation tools to include measured cross sections for DNA constituents to produce a complete data set of parameters to compare with biological experiments. The multi-scale model further included the ROS production rates from WP3 to model indirect effects. Its extended version for the prediction of late biological effects contained free parameters that were determined from the correlations between nanodosimetric parameters of track structure (as obtained in WP2) and the respective biological yields.

Work package 6, Creating Impact, created the impact from the JRP SIB06 BioQuaRT research by liaising with stakeholders; organising workshops to disseminate the results of the JRP SIB06 BioQuaRT; presenting results of the JRP SIB06 BioQuaRT at relevant conferences; and publishing the results obtained in this JRP SIB06 BioQuaRT in peer-reviewed papers.

Work package 7 related to the JRP SIB06 BioQuaRT Management and Coordination.