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Mathematical Modelling and Data Analysis

Department 8.4

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Title: Oscillations in the lateral pressure of lipid monolayers induced by nonlinear chemical dynamics of the second messengers MARCKS and protein kinase C
Author(s): S. Alonso, U. Dietrich, C. Händel, J. A. Käs and M. Bär
Journal: Biophys. J.
Year: 2011
Volume: 100
Issue: 4
Pages: 939--47
DOI: 10.1016/j.bpj.2010.12.3702
ISSN: 1542-0086
Web URL: http://www.sciencedirect.com/science/article/pii/S0006349510052197
Keywords: Biological,Biological Transport,Computer Simulation,Fluorescence,Intracellular Signaling Peptides and Proteins,Intracellular Signaling Peptides and Proteins: met,Lipids,Lipids: chemistry,Membrane Proteins,Membrane Proteins: metabolism,Microscopy,Models,Nonlinear Dynamics,Phosphorylation,Pressure,Protein Kinase C,Protein Kinase C: metabolism,Second Messenger Systems,Time Factors
Tags: 8.41,membrane
Abstract: The binding of the MARCKS peptide to the lipid monolayer containing PIP(2) increases the lateral pressure of the monolayer. The unbinding dynamics modulated by protein kinase C leads to oscillations in lateral pressure of lipid monolayers. These periodic dynamics can be attributed to changes in the crystalline lipid domain size. We have developed a mathematical model to explain these observations based on the changes in the physical structure of the monolayer by the translocation of MARCKS peptide. The model indicates that changes in lipid domain size drives these oscillations. The model is extended to an open system that sustains chemical oscillations.

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