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Mathematical Modelling and Data Analysis

Department 8.4

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Title: Latency analysis of single auditory evoked M100 responses by spatio-temporal filtering
Author(s): G. Wübbeler, A. Link, M. Burghoff, L. Trahms and C. Elster
Journal: Physics in medicine and biology
Year: 2007
Volume: 52
Issue: 15
Pages: 4383--92
DOI: 10.1088/0031-9155/52/15/002
ISSN: 0031-9155
Web URL: http://www.ncbi.nlm.nih.gov/pubmed/17634639
Keywords: Acoustic Stimulation,Acoustic Stimulation: methods,Algorithms,Diagnosis, Computer-Assisted,Diagnosis, Computer-Assisted: methods,Evoked Potentials, Auditory,Evoked Potentials, Auditory: physiology,Humans,Magnetoencephalography,Magnetoencephalography: methods,Pitch Perception,Pitch Perception: physiology,Reaction Time,Reaction Time: physiology,Reproducibility of Results,Sensitivity and Specificity
Tags: 8.42, Gehirn
Abstract: Appropriate spatial filtering followed by temporal filtering is well suited for the single-trial analysis of multi-channel magnetoencephalogram or electroencephalogram recordings. This is demonstrated by the results of a single-trial latency analysis obtained for auditory evoked M100 responses from nine subjects using two different stimulation frequencies. Spatial filters were derived automatically from the data via noise-adjusted principle component analysis, and single-trial latencies were estimated from the signal phase after complex bandpass filtering. For each of the two stimulation frequencies, estimated single-trial latencies were consistent with results obtained from a standard approach using averaged evoked responses. The quality of the estimated single-trial latencies was additionally assessed by their ability to separate between the two different stimulation frequencies. As a result, more than 80% of the single trials can be classified correctly by their estimated latencies.

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