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Mathematical Modelling and Data Analysis

Department 8.4

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Title: Tonic neuronal activation during simple and complex finger movements analyzed by DC-magnetoencephalography
Author(s): S. Leistner, G. Wübbeler, L. Trahms, G. Curio and B. M. Mackert
Journal: Neuroscience letters
Year: 2006
Volume: 394
Issue: 1
Pages: 42--7
DOI: 10.1016/j.neulet.2005.10.004
ISSN: 0304-3940
Web URL: http://www.sciencedirect.com/science/article/pii/S0304394005011523
Keywords: Adult,Brain Mapping,Evoked Potentials, Somatosensory,Evoked Potentials, Somatosensory: physiology,Evoked Potentials, Somatosensory: radiation effect,Female,Fingers,Fingers: physiology,Functional Laterality,Functional Laterality: physiology,Humans,Magnetoencephalography,Male,Motor Cortex,Motor Cortex: physiology,Motor Cortex: radiation effects,Movement,Movement: physiology,Movement: radiation effects,Psychomotor Performance,Psychomotor Performance: physiology,Psychomotor Performance: radiation effects,Somatosensory,Somatosensory: physiology,Somatosensory: radiation effect
Tags: 8.42, Gehirn
Abstract: Functional neuroimaging techniques map neuronal activation indirectly via local concomitant cortical vascular/metabolic changes. In a complementary approach, DC-magnetoencephalography measures neuronal activation dynamics directly, notably in a time range of the slow vascular/metabolic response. Here, using this technique neuronal activation dynamics and patterns for simple and complex finger movements are characterized intraindividually: in 6/6 right-handed subjects contralateral prolonged (30 s each) complex self-paced sequential finger movements revealed stronger field amplitudes over the pericentral sensorimotor cortex than simple movements. A consistent lateralization for contralateral versus ipsilateral finger movements was not found (4/6). A subsequent sensory paradigm focused on somatosensory afferences during the motor tasks and the reliability of the measuring technique. In all six subjects stable sustained neuronal activation during electrical median nerve stimulation was recorded. These neuronal quasi-tonic activation characteristics provide a new non-invasive neurophysiological measure to interpret signals mapped by functional neuroimaging techniques.

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