This file was created by the TYPO3 extension bib --- Timezone: CEST Creation date: 2024-04-19 Creation time: 06-52-46 --- Number of references 1 article lichtner_predicting_2021 Scientific Reports 2021 11 1 13205 Abstract In a pandemic with a novel disease, disease-specific prognosis models are available only with a delay. To bridge the critical early phase, models built for similar diseases might be applied. To test the accuracy of such a knowledge transfer, we investigated how precise lethal courses in critically ill COVID-19 patients can be predicted by a model trained on critically ill non-COVID-19 viral pneumonia patients. We trained gradient boosted decision tree models on 718 (245 deceased) non-COVID-19 viral pneumonia patients to predict individual ICU mortality and applied it to 1054 (369 deceased) COVID-19 patients. Our model showed a significantly better predictive performance (AUROC 0.86 [95% CI 0.86–0.87]) than the clinical scores APACHE2 (0.63 [95% CI 0.61–0.65]), SAPS2 (0.72 [95% CI 0.71–0.74]) and SOFA (0.76 [95% CI 0.75–0.77]), the COVID-19-specific mortality prediction models of Zhou (0.76 [95% CI 0.73–0.78]) and Wang (laboratory: 0.62 [95% CI 0.59–0.65]; clinical: 0.56 [95% CI 0.55–0.58]) and the 4C COVID-19 Mortality score (0.71 [95% CI 0.70–0.72]). We conclude that lethal courses in critically ill COVID-19 patients can be predicted by a machine learning model trained on non-COVID-19 patients. Our results suggest that in a pandemic with a novel disease, prognosis models built for similar diseases can be applied, even when the diseases differ in time courses and in rates of critical and lethal courses. http://www.nature.com/articles/s41598-021-92475-7 2021-10-14 en 2045-2322 10.1038/s41598-021-92475-7 GregorLichtner FelixBalzer StefanHaufe NiklasGiesa FridtjofSchiefenhövel MalteSchmieding CarloJurth WolfgangKopp AltunaAkalin Stefan J.Schaller SteffenWeber-Carstens ClaudiaSpies Falkvon Dincklage