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Databases of in silico pulse waves for haemodynamic studies

Kolloquium der Abteilung 8

Pulse wave (PW) signals are used for physiological assessment in both clinical medicine and consumer devices (e.g. smartwatches). They are influenced by the heart, vasculature, and respiratory and autonomic nervous systems,making them a rich source of information on cardiovascular function. Consequently, many indices and algorithms have been proposed to infer the physiological state of the cardiovascular system by analysing PW morphology. Acquiring comprehensive databases for assessingthe performance of these indices and algorithms is usually a complex task: (i) it can be difficult to measure reference variables precisely; (ii) it is challenging to study the influence of individual cardiovascular properties on the PW in vivo;(iii) it can be complex to measure PWs at all the sites of interest (particularly central arteries); (iv) clinical trials are expensive and time-consuming; and (v) in vivo measurements are subject to experimental error.

To facilitate this process, we have created databases of simulated PWs representative of samples of real subjects using computational blood flow modelling. This is a novel and cost-effective approach for the development and pre-clinical testing of PW analysis algorithms across a wide range of cardiovascular conditions, in a relatively quick and inexpensive manner. In silico PW databases also enable us to understand physical mechanisms underlying correlations observed from populations of real subjects andtrain machine-learning algorithms for PW analysis across a wide range of physiological conditions. This talk will show how these datasets can be created, verified and used in clinically relevant problems.  


Webstream: https://www.conf.dfn.de/stream/nr5hv5d7f8qae

Der Stream überträgt sowohl Bild als auch Audio. / The stream transmits both image and audio.

Fragen können über den auf der Webstream-Seite zurgänglichen Chat gestellt werden. / Questions can be ask via the chat below on the webstream website.

Zu diesem Kolloquium sind alle Interessenten herzlich eingeladen!

All interested parties are cordially invited to this colloquium!