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Finding genetic sequences plays a key role in modern medical diagnostics. Today genetic sequences are commonly determined by next-generation-sequencing (NGS) techniques. Applications include cancer diagnostics and detection of pathogens. Such NGS techniques also lead to the discovery of the SARS-CoV-2 virus.

PTB´s Institute Berlin held a workshop “Metrology Needs for Next-Generation-Sequencing”...

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Open-source practices and resources in MRI have increased substantially over the past years. This trend started with software and data being published open-source, but more recently open-source hardware designs are increasingly becoming available, too. The plentitude of open-source soft- and hardware products that are meanwhile available for all kind of MRI related purposes makes it increasingly...

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Originally developed for fast global sensitivity analysis and efficient parameter reconstruction for applications in nano-optical metrology, PyThia provides an all purpose non-intrusive Python package to approximate high dimensional functions.
Based on general polynomial chaos approximation obtained via linear regression, PyThia generates functional surrogates by relying purely on training data...

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Signal generation in magnetic resonance imaging (MRI) scanners relies on strong radio frequency fields. Monitoring and limiting the local energy deposition in the patient's body, measured via the specific absorption rate (SAR), represents a major challenge, especially when working with several transmit antennas in parallel. The SAR distribution cannot be measured directly but must be calculated...

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Abbildung: Deckblatt der deutschen Version des WELMEC Software Guides

The WELMEC Guide 7.2 "Software" is the most widely used WELMEC guide in Europe and is now also available in German in its updated and revised version 2023. 

The translation was coordinated between the three countries Germany, Switzerland and Austria and has been available on the WELMEC website since November 2023 (www.welmec.org). 

The template of the German revision is the basis for determining...

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We introduced a novel approach involving low-rank matrix reconstruction, applied to the sub-diffraction technique of atomic force microscopy-based infrared spectroscopy (AFM-IR), thereby enabling highly efficient hyperspectral infrared nanoimaging. Its practical utility was demonstrated on Leishmania parasites as a realistic target of biological importance.

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Diffuse optical imaging allows the characterization of physiological parameters of tumors in the breast. By using appropriate wavelengths in the near-infrared spectral region, the concentrations of oxygenated and deoxygenated hemoglobin, as well as water and collagen content, can be estimated. In the scanning method shown in the left figure, picosecond laser pulses are broadened by the strong...

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Artificial intelligence is a powerful tool to assist physicians in diagnosing diseases. We extended this line of research by applying modern machine learning methods to the field of image quality assessment for mammography. Mammography is an established diagnostic technique to detect early forms of breast cancer. However, to ensure that a sufficient image quality can be obtained with a minimal...

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Abbildung: Deckblatt des zusammenfassenden Berichts des 58. Treffens des internationalen Komitees des gesetzlichen Messwesens (CIML) in Thailand im Oktober 2023.

Das Internationale Komitee für das gesetzliche Messwesen (CIML) hat auf seiner diesjährigen Sitzung das überarbeitete Internationale Dokument D31 der Internationalen Organisation für das gesetzliche Messwesen (OIML) mit weltweit einheitlichen Softwareanforderungen an Messgeräte bewilligt (CIML meeting Sites, Resolutions, Minutes — English (oiml.org)). 

Der neue D31 adressiert unter anderem die...

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Blockbild Risikoanalyse

Die PTB ist durch die Gewerbeordnung (GewO) mit der Bauartzulassung von Spielgeräten mit Gewinnmöglichkeiten beauftragt. Weitere Details werden in der Spielverordnung (SpielV) festgelegt. In der PTB führt die AG 8.53 „Spielgeräte“ diese Aufgabe seit vielen Jahren sehr verantwortungsbewusst durch. 

In der letzten Anpassung der SpielV wurden verschärfte Regelinstrumente zur Sicherung des Spieler-...

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