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Die Europäische Kooperation im gesetzlichen Messwesen WELMEC (European Cooperation in Legal Metrology) trifft sich jährlich im Rahmen ihrer Generalversammlung als deren zentrales Entscheidungsgremium. In der Generalversammlung berichten u.a. die Vorsitzenden der verschiedenen WELMEC-Arbeitsgruppen den Delegierten der europäischen Mitgliedsstaaten und dem Vertreter der europäischen Kommission über...

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In many clinical MRI examinations, contrast agents containing Gd are used to better visualize blood vessels or certain organs. Since it was discovered about 10 years ago that this can lead to long-term depositions of gadolinium in the brain, the question of the underlying mechanisms -when and how are such depositions occurring?- has been of the highest scientific interest. Patrick Schünke from...

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Together with scientists from the German Cancer Research (DKFZ) in Heidelberg and the Leibniz institute for molecular pharmacology (FMP) in Berlin, Patrick Schünke (PTB) published an article in the scientific journal Physical Chemistry Chemical Physics. The article entitled "Rapid analytical CEST spectroscopy of competitive host–guest interactions using spatial parallelization with a combined...

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Xenon noble gas atoms can form transient complexes with host molecules in solution. The resulting host-guest systems are held together by non-covalent bonds. They are an example of supramolecular systems. They may thus serve for the analysis of similar chemical or pharmaceutical carrier and delivery systems. Xenon complexation is currently also explored as potential contrast agent in magnetic...

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Artificial intelligence (AI, e.g., deep learning) is increasingly used to assist high-stakes decisions in areas such as finance, medicine, or autonomous driving. Upcoming regulations will require that the principles by which such algorithms arrive at their predictions should be transparent. However, while numerous “explainable” AI (XAI) methods have been proposed, the field is lacking formal...

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Virtual experiments simulating real measurement processes by means of numerical models have become increasingly important in modern metrology and industrial applications. Combined with Monte Carlo methods, virtual experiments have also been proposed for the evaluation of measurement uncertainties for a corresponding real experiment. However, such a proceeding is not always in line with the current...

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Zur Konformitätsbewertung von Messgeräten, die dem Mess- und Eichgesetz unterliegen, gehört auch die Prüfung der Absicherung des darunterliegenden Universal-Betriebssystems. Unter bestimmten Voraussetzungen ist es möglich, solche Betriebssysteme über deren Konfiguration abzusichern, um die Anforderungen des europäisch harmonisierten WELMEC 7.2 Softwareleitfadens zu erfüllen.

Für den...

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Originally developed for fast global sensitivity analysis and efficient parameter reconstruction for applications in nano-optical metrology, PyThia provides an all purpose non-intrusive Python package to approximate high dimensional functions. Based on general polynomial chaos approximation obtained via linear regression, PyThia generates functional surrogates by relying purely on training data...

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Histogram of fluorescence seperates positive and negative measurement resultsPCR tests were used already at the beginning of the covid-19 pandemic. SARS-CoV-2 is an RNA virus. However, PCR can only detect DNA. Therefore, RNA is first transcribed into DNA. Next the DNA is specifically amplified. A high viral concentration generates a strong signal. This allows to use a PCR test to detect or exclude an infection by SARS-CoV-2. The analytical sensitivity of PCR tests can vary...

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