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Quantitative analysis of xenon exchange kinetics with molecular hosts


Xenon noble gas atoms can form transient complexes with host molecules in solution. The resulting host-guest systems are held together by non-covalent bonds. They are an example of supramolecular systems. They may thus serve for the analysis of similar chemical or pharmaceutical carrier and delivery systems. Xenon complexation is currently also explored as potential contrast agent in magnetic resonance imaging. A key feature is the kinetics of association and dissociation of xenon with the host molecules. Usually, application of various experimental techniques and respective procedures for data evaluation is required for analysis. However, a novel magnetic resonance spectroscopic approach developed at PTB allows a singly method to be applied for the comprehensive evaluation of the exchange kinetics. Hence, accuracy and comparability of the quantitative data is furthered. The xenon atoms are prepared for the measurement by so-called hyperpolarization techniques. Thus excellent sensitivity is achieved. In addition, cumbersome calibration procedures are avoided if metrological data on the xenon solubility are available. The approach was published recently. It may support progress in supramolecular chemistry, pharmacology and medical imaging based on quantitative xenon exchange.

Mitschang L, Korchak S, Kilian W, Riemer T.
Comprehensive Quantitative and Calibration-Free Evaluation of Hyperpolarized Xenon–Host Interaction by Multiparametric NMR
Anal. Chem. 94 (2022); DOI: 10.1021/acs.analchem.1c04482