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Standardized technical validation of biophotonic devices is indispensable for the reliability and reproducibility of measurement results in their medical use. This requires suitable standardized phantoms, i.e., tissue-like test specimens, and recognized standards for evaluating the performance of these devices. Both prerequisites are not sufficiently met in the field of medical optical imaging. A...

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Accurate measurement of the concentration of cells in blood is important for diagnosis or therapy monitoring of many diseases. The comparability of the measurement results within a laboratory and between different laboratories is critical for patient safety. To assure comparability of the measurement methods, so-called reference measurement procedures for the determination of cell concentrations...

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Xenon noble gas atoms can form transient complexes with host molecules in solution. The resulting host-guest systems are held together by non-covalent bonds. They are an example of supramolecular systems. They may thus serve for the analysis of similar chemical or pharmaceutical carrier and delivery systems. Xenon complexation is currently also explored as potential contrast agent in magnetic...

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Histogram of fluorescence seperates positive and negative measurement resultsPCR tests were used already at the beginning of the covid-19 pandemic. SARS-CoV-2 is an RNA virus. However, PCR can only detect DNA. Therefore, RNA is first transcribed into DNA. Next the DNA is specifically amplified. A high viral concentration generates a strong signal. This allows to use a PCR test to detect or exclude an infection by SARS-CoV-2. The analytical sensitivity of PCR tests can vary...

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The Department of Biomedical Optics has started a technology transfer collaboration with NIRx-Medizintechnik GmbH. This involves the development and testing of wearable devices for determining oxygen saturation in the human brain. The measurement method is based on the application of near-infrared light. The devices were extensively characterized at PTB. Reference phantoms developed by PTB with...

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