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Biomedical Optics

Department 8.3

Tasks

We develop and investigate optically supported quantitative measurement and imaging methods for medical diagnostics and therapy control, mostly in collaboration with clinical partners. The focus of activities of the working group 8.31 is on optical spectroscopy and imaging for non-invasive quantitative determination of important biomarkers (e.g. hemoglobin concentration, oxygen saturation) in tissue in vivo as well as for the visualization of disease-related molecular changes by means of fluorescence-labeled probes. In addition, microscopic imaging techniques are developed and studied for the characterization and differentiation of single biological cells in flow. In working group 8.32, flow cytometric and microscopic measurement methods for cells as well as molecular biological measurement methods for the detection and quantification of pathogens (e.g. viruses such as HIV and SARS-CoV2, or bacteria) are investigated for metrology in laboratory diagnostics. The aim is, among other things, the development of reference measurement methods as well as the determination of reference measurement values for external quality assurance schemes which are legally required for medical laboratories.

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