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Biomedical Optics

Department 8.3


We develop and investigate optically supported quantitative measurement and imaging methods for medical diagnostics and therapy control, mostly in collaboration with clinical partners. The focus of activities of the working group 8.31 is on optical spectroscopy and imaging for non-invasive quantitative determination of important biomarkers (e.g. hemoglobin concentration, oxygen saturation) in tissue in vivo as well as for the visualization of disease-related molecular changes by means of fluorescence-labeled probes. In addition, microscopic imaging techniques are developed and studied for the characterization and differentiation of single biological cells in flow. In working group 8.32, flow cytometric and microscopic measurement methods for cells as well as molecular biological measurement methods for the detection and quantification of pathogens (e.g. viruses such as HIV and SARS-CoV2, or bacteria) are investigated for metrology in laboratory diagnostics. The aim is, among other things, the development of reference measurement methods as well as the determination of reference measurement values for external quality assurance schemes which are legally required for medical laboratories.


Standardized technical validation of biophotonic devices is indispensable for the reliability and reproducibility of measurement results in their medical use. This requires suitable standardized phantoms, i.e., tissue-like test specimens, and recognized standards for evaluating the performance of these devices. Both prerequisites are not sufficiently met in the field of medical optical imaging. A...

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Accurate measurement of the concentration of cells in blood is important for diagnosis or therapy monitoring of many diseases. The comparability of the measurement results within a laboratory and between different laboratories is critical for patient safety. To assure comparability of the measurement methods, so-called reference measurement procedures for the determination of cell concentrations...

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Xenon noble gas atoms can form transient complexes with host molecules in solution. The resulting host-guest systems are held together by non-covalent bonds. They are an example of supramolecular systems. They may thus serve for the analysis of similar chemical or pharmaceutical carrier and delivery systems. Xenon complexation is currently also explored as potential contrast agent in magnetic...

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