Lead, cadmium, mercury, and arsenic do not belong in medicinal products. International requirements for the quality of medicines have therefore become more stringent and introduced new control requirements. Hence, it makes sense to use high-accuracy reference solutions with defined contents of these four elements to be able to make the measurements traceable to the International System of Units (SI). Such reference solutions have now been produced in a joint project of the European Directorate for the Quality of Medicines and HealthCare (EDQM), the Joint Research Center (JRC) Geel, the German Federal Institute for Materials Research and Testing (BAM) and the Physikalisch-Technische Bundesanstalt (PTB). Since January 2018, they are commercially available at the EDQM.
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