Organic Analysis

Tasks

• Quantitative Analysis of organic substances in complex matrix..
• Development of Reference Measurement Procedures using mass spectrometry.
  
• Determination of diagnostic markers¹ in clinical samples.
• Supporting quality in medical practice by providing target values in proficiency testing schemes and comparative measurements with clinical Reference Laboratories².
• Participating in international studies on traceability and comparability of such analyses.
• Participating in certification of Standard Reference Materials, e.g. NIST-SRM 971³.

Services

• List of measurement capabilities⁴.

Research

• Analytical Biochemistry: Protein analysis by mass spectrometry.
• Quantitative Proteomics. „Absolute“ quantification of proteins using IDMS.
• Quantification of growth hormone (GH, somatotropin) from serum.
• H/D exchange kinetics for obtaining thermodynamic data on proteins.
• Characterization of protein structures by chemical x-linking. 

Publications              

Projects

• EU- Projekt „Feasibility to develop reference measurement systems for Thyrotropin (TSH) and for free Thyroxine (FT4), and validation of reference measurement systems (procedure and material for Thyroxine (T4) and Triiodothyronine (T3). 5^th Framework programme of the European Commission. (finished)
• European Metrology Research Programme (EMRP), contribution “Traceability of complex biomolecules and biomarkers in diagnostics- effecting measurement comparability in clinical medicine”, (TP2 health)^5,6.

Contact

Head of Working Group		Dr.rer.nat. André Henrion Tel.: +49 (0)531-592-3120
Office		Steffi Siegfried Tel.: +49 (0)531-592-3101 Fax: +49 (0)531-592-3015
Address		Physikalisch-Technische Bundesanstalt Arbeitsgruppe 3.12 Bundesallee 100 38116 Braunschweig