Physikalisch-Technische Bundesanstalt

Tasks

• Quantitative Analysis of organic substances in complex matrix..
• Development of Reference Measurement Procedures using mass spectrometry.
  
• Determination of diagnostic markers¹ in clinical samples.
• Supporting quality in medical practice by providing target values in proficiency testing schemes and comparative measurements with clinical Reference Laboratories².
• Participating in international studies on traceability and comparability of such analyses.
• Participating in certification of Standard Reference Materials, e.g. NIST-SRM 971³.

Services

• List of measurement capabilities⁴.

Research

• Analytical Biochemistry: Protein analysis by mass spectrometry.
• Quantitative Proteomics. „Absolute“ quantification of proteins using IDMS.
• Quantification of growth hormone (GH, somatotropin) from serum.
• H/D exchange kinetics for obtaining thermodynamic data on proteins.
• Characterization of protein structures by chemical x-linking.

Projects

• European Metrology Research Programme (EMRP), Beitrag “Metology for biomolecular origin of disease (BiOrigin, HLT10)
• European Metrology Research Programme (EMRP), Beitrag "Metrology for metalloproteins (Metallomics, HLT05)
• EU- Projekt "Feasibility to develop reference measurement systems for Thyrotropin (TSH) and for free Thyroxine (FT4), and validation of reference measurement systems (procedure and material) for Thyroxine (T4) and Triiodothyronine (T3) in human". 5^th Framework programme of the European Commission. (finished)
• European Metrology Research Programme (EMRP), Beitrag “Traceability of complex biomolecules and biomarkers in diagnostics- effecting measurement comparability in clinical medicine”, (TP2 health, T2.J.11)^{5, 6}. (finished 2011)

Publications

       André Henrion   Cristian Arsene   Hamdin Cakar    Anita Röthke     Michael Rettig